Here are some of the best zingers of the night:

Jon Lovitz: “[Charlie Sheen] is nothing like the character he plays on TMZ.” 

Kate Walsh: “I have to say, Charlie, you are an incredible medical specimen. I guess that’s one of the benefits of waking up every morning at the crack of crack…It’s amazing. After abusing your lungs, liver and kidneys, the only thing you’ve had removed is your kids.” 

Jeffrey Ross: “This lineup [of those roasting] is so pathetic I was hoping I’d get replaced by Ashton Kutcher…Charlie’s meltdown was so bad Al Gore is making a documentary about it.”

Mike Tyson: “Hey Charlie Sheen! Now props to the f*cking guy man he’s got big protruding balls he’s gonna bust your stool man.”

Anthony Jeselnik: “Charlie, you are a monster. Every moment of your life looks like the first two minutes of ‘Law and Order, SVU.’”

Amy Schumer (To Mike Tyson): “You have a slutty lower back tattoo on your face.”

Amy Schumer (To Charlie Sheen): “You’re just like Bruce Willis—you were big in the 80s and now your old slot is being filled byAshton Kutcher.”

William Shatner: “Prostitutes cost a lot of money, Charlie! Hasn’t anyone told you that actresses will sleep with you for free? That’s Hollywood 101! You should’ve called.”

Patrice O’Neal (To audience): “F—ck you. Y’all laughed at some f-cked up sh-t.”

Steve-O: “Charlie still hasn’t hit rock bottom. He’s looking forward to it though, because he thinks there’s a rock there.”

Charlie Sheen: “It’s true, I’ve hung around with a lot of shady people over the years — losers, drug addicts, dealers, desperate whores. But to have you all here on one night is really special.”